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The sickle cell anemia the mutation occurs at the

( a ) gamma globin chain
( b ) alpha globin chain
( c ) delta globin chain
( d ) beta globin chain
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Ans: (D): beta globin chain
Sickle cell anaemia is caused by the substitution of glutanic acid by Valine at the sixth position of the beta globin of the Hb molecule. The substitution of aminoacid in the globin protein results due to single base substitution at the sixth codon of the betaglobin gene from GAG to GUG.
answered Nov 3, 2016 by suganyadevi.p
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