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In the first step of fatty acid biosynthesis, the carboxylation of acetyl CoA to fom malonyl CoA is catalyzed by the enzyme acetyl CoA carboxylase, that has _______ as a cofactor.

( A ) Vitamin B12
( B ) Biotin
( C ) NADP+ (nicotinamide adenine dinucleotide phosphate)
( D ) NAD+ (nicotinamide adenine dinucleotide)
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