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The relative reactivities of acyl compounds towards nucleophilic substitution are in the order of :

(1)Acylchloride>Ester>Acidanhydride>Amide(2)Acylchloride>Acidanhydride>Ester>Amide(3)Ester>Acylchloride>Amide>Acidanhydride(4)Acidanhydride>Amide>Ester>Acylchloride

 

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